There have been rare post-marketing reports of fatal and, CRESTOR should be used with caution in patients who consume substantial quantities of alcohol, CRESTOR significantly increased INR in patients receiving coumarin anticoagulants. In patients taking coumarin anticoagulants and CRESTOR concomitantly, INR should be determined before starting CRESTOR and frequently enough during early therapy to ensure that no significant alteration of INR occurs, Dipstick-positive proteinuria and microscopic hematuria were observed among patients treated with CRESTOR. Mean baseline LDL-C: 187 mg/dL. These risks can occur at any dose level, but are increased at the highest. †P<.002 vs simvastatin 10 mg, 20 mg; pravastatin 10 mg, 20 mg, 40 mg. ‡P<.002 vs atorvastatin 20 mg; simvastatin 20 mg, 40 mg; pravastatin 20 mg, 40 mg. §P<.002 vs simvastatin 40 mg; pravastatin 40 mg. P=NS CRESTOR 10 mg vs atorvastatin 10 mg, 20 mg, 40 mg; simvastatin 40 mg. P=NS CRESTOR 20 mg vs atorvastatin 40 mg, 80 mg; simvastatin 80 mg. P=NS CRESTOR 40 mg vs atorvastatin 40 mg, 80 mg; simvastatin 80 mg. Restrictions apply. Be sure to compare this price with your insurance costs to see which option will be the cheapest. Click here for eligibility information. Read full Prescribing Information (PDF - 152k). The study performed the following dose comparisons: CRESTOR 10 mg vs simvastatin 10 mg, 20 mg, and 40 mg; CRESTOR 20 mg vs simvastatin 20 mg, 40 mg, and 80 mg; and CRESTOR 40 mg vs simvastatin 40 mg and 80 mg. Percentage of patients achieving LDL-C <100 mg/dL was not a prospectively planned analysis. The starting dose for most adults is 5 mg once daily. This medicine can be taken with or without food, but it must be swallowed whole and never crushed, broken apart or chewed. Adapted from the STELLAR trial.1,5 STELLAR was a 6-week, multicenter, open-label, randomized, 15-arm trial comparing the efficacy and safety of CRESTOR with atorvastatin, simvastatin, and pravastatin in 2240 patients with hyperlipidemia or mixed dyslipidemia. The trick is to weigh the potential for serious side effects against the gain you can get from the medication. DE. The generic version, as you can see, will be much less than the branded pill. You can read the restrictions and download the card by clicking here. For detailed comparative clinical trial data on LDL-C goal attainment or LDL-C reductions, click on the appropriate tab below. If your doctor does recommend this type of diet, just like the medicine, it will be important to follow the directions closely. Crestor. Answered by : Dr. Niranjan G ( Diabetologist) Suggest treatment for high cholesterol MD. AstraZeneca Pharmaceuticals LP. Crestor’s manufacturer does recommend a lower 5-mg dose for people requiring “less aggressive LDL … Prescribing Information with Patient Information (PDF - … Lipitor is a registered trademark of Pfizer Inc. You may report side effects related to AstraZeneca products by clicking here. Following a 6-week dietary lead-in period, patients were randomized to receive CRESTOR 10 mg or atorvastatin 10 mg for 6 weeks. Lipitor may be taken with or without food and at any time of day. ©2018 AstraZeneca. The primary end point was percentage change from baseline in LDL-C at Week 6. Statistical comparisons were not made across the dose range, only across the same time period. Please read our disclosure policy for more info. Splitting a 40mg pill, for instance, can create two 20mg pills, but it will cost 50 percent than the same amount of a 20mg equivalent. Percentage of patients achieving LDL-C <100 mg/dL was not a prospectively planned analysis. Data on File, 268255. The primary end point was percentage of patients achieving NCEP ATP III LDL-C goal of <100 mg/dL at Week 24. Watch Expert Panel Discussion on Assessing LDL-C Goals, In the STELLAR trial in patients with hyperlipidemia or mixed dyslipidemia nearly 9 out of 10 met their LDL-C goal with CRESTOR 20 mg*5. The primary end point was percentage change from baseline in LDL-C at week 6. The primary end point was percentage change from baseline in LDL-C at week 6. AstraZeneca Pharmaceuticals LP, Wilmington, Analysis of this goal was added to the statistical analysis plan before unblinding of the study data. dasabuvir/ombitasvir/paritaprevir/ritonavir. In some cases, you may be able to split your pills, helping you save up to 50 percent; however, before doing so, ask your doctor if splitting can work for your situation. 12 Some people, especially those with serious coronary disease, require this degree of LDL-C reduction, but most people with elevated cholesterol require only 20%-30% reductions — and therefore much less medication. For the generic, plan on your co-pay, depending on your insurance and the quantity you’re purchasing, ranging anywhere from $0 to $65. Pediatric patients should receive 10 mg once daily up to a maximum dose of 20 mg daily. †P<.002 CRESTOR 10 mg vs pravastatin 10 mg, 20 mg, 40 mg. ‡P<.002 CRESTOR 20 mg vs pravastatin 20 mg, 40 mg. §P<.002 CRESTOR 40 mg vs pravastatin 40 mg. Adapted from the STELLAR trial.1,5,6 STELLAR was a 6-week, multicenter, open-label, randomized, 15-arm trial comparing the efficacy and safety of CRESTOR with atorvastatin, simvastatin, and pravastatin in 2240 patients with hyperlipidemia or mixed dyslipidemia. *P<.001 vs atorvastatin during same time point (eg, Week 6). Mean baseline LDL-C: 188 mg/dL to 189 mg/dL. The standard starting dose of Crestor is 10 mg, which reduces LDL-C a whopping 46%-52%. The study performed the following dose comparisons: CRESTOR 10 mg vs atorvastatin 10 mg, 20 mg, and 40 mg; CRESTOR 20 mg vs atorvastatin 20 mg, 40 mg, and 80 mg; and CRESTOR 40 mg vs atorvastatin 40 mg and 80 mg. This product information is intended for US Health Care Professionals only. GoodRX.com, for example, allows you to print out a coupon for free and take it to a local pharmacy to receive the cost printed on the card. The study performed the following dose comparisons: CRESTOR 10 mg vs atorvastatin 10 mg, 20 mg, and 40 mg, simvastatin 10 mg, 20 mg, and 40 mg, and pravastatin 10 mg, 20 mg, and 40 mg; CRESTOR 20 mg vs atorvastatin 20 mg, 40 mg, and 80 mg, simvastatin 20 mg, 40 mg, and 80 mg, and pravastatin 20 mg and 40 mg; and CRESTOR 40 mg vs atorvastatin 40 mg and 80 mg, simvastatin 40 mg and 80 mg, and pravastatin 40 mg. If you know you’re going to use the medicine for more than 90 days, then ask your doctor if he or she is able to write a longer prescription. Click on the "+" and "—" signs to expand and collapse the clinical information. Secondary end points included achievement of NCEP ATP III goal. Never use more, less or take it on a schedule of your choice. Upsides. While this medicine is known to slow down other medical problems, often related to fats that clog the arteries, it can also help prevent a certain type of blood vessel and/or heart problems in patients who are higher at risk with heart problems. Again, talking with your doctor, see if other statin class drugs can help save you money such as Lipitor or Zocor. The study performed the following dose comparisons: CRESTOR 10 mg vs pravastatin 10 mg, 20 mg, and 40 mg; CRESTOR 20 mg vs pravastatin 20 mg and 40 mg; and CRESTOR 40 mg vs pravastatin 40 mg. Medicare will not cover the branded Crestor. In high-risk patients in the ECLIPSE trial, CRESTOR helped more patients achieve LDL-C goal than Lipitor® (atorvastatin calcium)2. CRESTOR should be prescribed with caution in patients with predisposing factors for myopathy (eg, Therapy with CRESTOR should be discontinued if markedly elevated CK levels occur or myopathy is diagnosed or suspected. 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Crestor, a prescription drug used to lower cholesterol levels, is available as a branded version, Crestor, and generic version, rosuvastatin. Crestor, belonging to a group of drugs called HMG-CoA reductase inhibitors, or statin, is commonly used together with a doctor recommended diet to help control your cholesterol and the fats (triglycerides) in your bloodstream. A pill splitter can cost less than $10. CRESTOR is a registered trademark of the AstraZeneca group of companies. Some simple steps can help minimize or avoid muscle problems from Crestor and other cholesterol-lowering drugs. Always, as with any prescription, use as recommended by your doctor’s orders. After a median treatment duration of 16 weeks, rosuvastatin 5 mg/d+diet was associated with a mean (SD) decrease from baseline in LDL-C of 75 (34) mg/dL (mean [SD] %Delta, -42% [18%]) (P<0.001 vs … Private insurance companies and Medicare will cover the generic rosuvastatin, but according to GoodRX.com, Medicare will not cover the branded Crestor. All patients treated with CRESTOR should be advised to promptly report any symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice. Prescribing Information for CRESTOR. In this section, you can review LDL cholesterol reduction results and LDL cholesterol goal attainment results from comparative clinical trials in which CRESTOR ® (rosuvastatin calcium) was used as an adjunct to diet in adult patients starting statin therapy. The cost of Crestor depends on a few factors, just like any prescription drugs, including the dosage strength, whether you’re purchasing the generic, your health insurance policy and the pharmacy you choose. In this section, you can review LDL cholesterol reduction results and LDL cholesterol goal attainment results from comparative clinical trials in which CRESTOR® (rosuvastatin calcium) was used as an adjunct to diet in adult patients starting statin therapy. Never use more, less or take it on a schedule of your choice potential for serious how much will 5 mg crestor lower cholesterol related...: Dr. Niranjan G ( Diabetologist ) Suggest treatment for high cholesterol MD the clinical information to taking. Statistical analysis plan before unblinding of the AstraZeneca group of companies helped more patients achieve LDL-C goal Lipitor®! The prescription coupon-based websites can help you save money all programs/services which may taken. 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