Return to: Papillary Thyroid Carcinoma Overview. These follicular cells have relatively wide cytoplasm and elongated large nuclei. These are the scarred remnants of tumor papillae that presumably infarcted. Basic Histopathologic Concepts for the Diagnosis and Classification of Thyroid Carcinoma. The authors report five examples of macrofollicular variant of papillary thyroid carcinoma with minor insular component. However, whether a predominant insular component is an ... recognized as a feature of the macrofollicular variant of papillary thyroid carcinoma; however, it does not appear to affect the excellent prognosis of patients This process is also called anaplastic transformation, and the morphological harbingers of this phenomenon in nodal recurrence have not been assessed systematically. In Case 3, the PDTC was present as a focus within an encapsulated follicular variant of papillary thyroid carcinoma with capsular and lymphovascular invasion. The tall cell variant of papillary thyroid carcinoma is the most common aggressive variant of papillary thyroid carcinoma. SVPTC is histologically characterized by predominant solid, trabecular and insular nests of tumor cells while cytological features of PTC such … 2010;23(9):1191-1200.Google Scholar Crossref Papillary thyroid cancer accounts for eight out of 10 thyroid cancer cases. Very rare. ... or nested (insular) appearance. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. We investigated whether the diffuse sclerosing variant of papillary carcinoma (diffuse sclerosing PC) and insular carcinoma (IC), two different subforms of differentiated carcinoma of the thyroid gland, have different clinical behaviors and prognosis in order to select appropriate therapy. Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) usually occurs in the setting of familial adenomatous polyposis (FAP) although it can rarely arise sporadically. It accounts for about 80% of all thyroid cancers. Solid variant of papillary thyroid carcinoma (SVPTC) is a rare morphological variant of papillary thyroid carcinoma (PTC). Albores-Saavedra J (1), Gould E, Vardaman C, Vuitch F. (1)Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072. Papillary carcinoma (PC) is the most common malignancy of thyroid follicular epithelium. Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer, representing 75 percent to 85 percent of all thyroid cancer cases. Epidemiology: Poor prognosis. The 10-year overall survival was 85.4% for WDPTC and 79.2% for DSV, 71.9% for TCV, 45.1% for PDTC, 27.9% in the insular variants, and 8.9% for anaplastic cases. For this reason, the current study focused on features of 10 PTCs with regional lymph node recurrence that was accompanied … 1 These tumors are diagnosed using characteristic nuclear morphology; however, within the classification of "papillary thyroid carcinoma," there exist several distinct architectural and cytologic subtypes. Epidemiology. Histopathological Variants of Papillary Carcinoma Thyroid Conventional Papillary Carcinoma Thyroid. Women are three times more likely to have papillary thyroid cancer than men are. Microscopic. It occurs more frequently in women and presents in the 20–55 year age group. Poorly differentiated thyroid carcinoma (PDTC) is a follicular cell-derived neoplasm with more aggressive behavior than well-differentiated carcinomas such as CMVPTC. The macrofollicular variant of papillary thyroid carcinoma: a study of 17 cases. 21 We believe that more studies with prolonged follow‐up are needed to understand better the natural history of thyroid neoplasms with an insular component, including the macrofollicular variant of papillary thyroid carcinoma. insular carcinoma: a poorly differentiated thyroid malignant tumor that grows in the form of large solid nests (insulae) and sheets, showing broad areas of necrosis. The pathological diagnosis of PTC is usually an easy diagnosis in the majority of cases. "Minimal" papillary features. Papillary thyroid cancer generally grows very slowly, but can often spread to lymph nodes in the neck. The shape of these tumor cells, 2‐ to 3‐times taller than wide, characterizes this aggressive variant. Case 5 … Papillary thyroid cancer is the most common type of thyroid cancer. These included 415 diffuse sclerosing variant, 3,339 tall cell variant, 362 insular variant and 1,331 poorly differentiated thyroid carcinoma cases. Also, adults between the ages of 20 to 60 years are more likely to develop this cancer than other age groups. Clinical forms of presentation and evolution of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyroid. Albareda M(1), Puig-Domingo M, Wengrowicz S, Soldevila J, Matias-Guiu X, Caballero A, Chico A, De Leiva A. There are following subtypes of papillary thyroid carcinoma: classic variant, follicular variant, tall cell variant, diffuse sclerosis variant, columnar cell variant, solid variant, insular variant, and poorly differentiated variant. The World Health Organization recognizes an insular component only in follicular carcinomas. To present a case of an insular variant of poorly differentiated thyroid carcinoma (PDTC) and to review the literature related to diagnosis, natural h… ; Nuclear stratification - key feature. Features: Elongated nuclei (similar to colorectal adenocarcinoma) - key feature. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid, contributing to over 70% of thyroid cancers. Dear Dr. Bedrossian, Being the most common neoplasm of the thyroid gland, papillary thyroid carcinoma (PTC) is the thyroid carcinoma that has been searched most and has had most number of variant. It also can spread elsewhere in the body. Terminology. ... Variants of Papillary Thyroid Carcinoma There are several subtypes or variants of PTC; common subtypes include follicular, tall cell, and diffuse sclerosing variants. It is more common in women with an M:F ratio of 1:2.5 (range 1:1.6-3:1) 2. Synonym(s): primordial cell carcinoma Macrofollicular variant of papillary thyroid carcinoma (MFV-PTC) was described in 1991 by Albores-Saavedra et al [].It is a rare variant of papillary carcinoma with a frequency of 2.6% [], characterized by highly dilated thyroid follicles in more than 50% of the neoplasm and resembles thyroid adenoma or nodular colloid goiter.Most have a good prognosis and are generally encapsulated. In the recent decades an obvious increase in the incidence of PTC has occurred. A papillary thyroid carcinoma is designated as solid/trabecular variant when all or nearly all of a tumor not belonging to any of the other variants has a solid, trabecular, or nested (insular) appearance. Tall cell papillary carcinoma (TCPC) and insular carcinoma (IC) are variants of thyroid carcinoma that are considered to be more aggressive than well differentiated papillary or follicular carcinoma. (1,7) Some authors have recommended that insular carcinoma be classified as a poorly differentiated thyroid tumor that is less aggressive than undifferentiated or anaplastic thyroid carcinoma, while others have suggested that insular carcinoma is an aggressive variant of a well-differentiated thyroid cancer that manifests insular features." Solid papillary thyroid carcinoma (SV-PTC) is a rare variant which is mainly observed in young patients with a history of exposure to ionising radiations. Anaplastic thyroid cancer is also known as undifferentiated thyroid cancer. (a) Tall cell variant papillary thyroid carcinoma with a trabecular growth pattern. … Mod Pathol. Most anaplastic thyroid carcinomas (ATCs) arise from papillary thyroid carcinoma (PTC). 1998 May;8(5):385-91. Insular thyroid carcinoma was described originally as a tumor with aggressive behavior. Insular thyroid carcinoma is referred to as poorly differentiated thyroid cancer. For comparison, anaplastic thyroid carcinoma (8021) cases were selected, as were WDPTC cases (papillary carcinoma not otherwise specified [8050], papillary carcinoma of thyroid [8260], follicular variant of PTC [8340], papillary microcarcinoma [8341], and encapsulated papillary carcinoma [8343]). 1. Despite the propensity for lymphatic dissemination to cervical nodes, … Rivera M, Ricarte-Filho J, Knauf J, et al. Papillary thyroid cancer (as is the case with follicular thyroid cancer) typically occurs in the middle-aged, with a peak incidence in the 3 rd and 4 th decades. Follicular variant. Papillary thyroid carcinoma columnar cell variant General. Thyroid. Papillary carcinoma of the thyroid (PTC) is the commonest thyroid cancer. A unique variant of PTC with different genetic profile. When the tumor measures <1 cm, the term micropapillary carcinoma (mPTC) is used 14.. Twenty-four cases of the tall cell variant (TCV), a subset of papillary thyroid carcinoma, were identified in a group of 624 patients with thyroid cancer. +/-Pseudostratification of the nuclei (like in colorectal adenocarcinoma), differentiates from tall cell variant. The aggressive behavior has been ascribed to the histologic subtype and/ or to the clinicopathologic features, an issue that remains controversial.
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