This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. You are using a version of browser that may not display all the features of this website. Proc Natl Acad Sci U S A. Collagen Type I Alpha 1 Chain is also known as Alpha-1 type I collagen, CO1A1, COL1A1, Cola1, Collagen alpha-1(I) chain, collagen I, Collagen I,II,III,IV,V, Collagen Types I, III, PICP . The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are … Molecular Reagents less. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Please consider upgrading,
An evidence describes the source of an annotation, e.g. Nach oben. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. IPR013320 Concanavalin A-like lectin/glucanase domain superfamily. Storage Condition and Buffer: an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
(1992) isolated from a human rhabdomyosarcoma cell line a 1.8-kb cDNA encoding a portion of a novel collagen chain with a structure similar to that of the FACIT class of macromolecules. UniProtKB. Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene. using the generator polynomial: x64 + x4 + x3 + x + 1. One type of transcript does not contain the sequence encoded by exon 1*; the second type of transcript contains this exon.
Contact Resources Top Antigen Products Popular Categories. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. At this point, Collagen, type XI, alpha 1 (COL11A1), might be helpful since it has been described to be associated to cancer associated fibroblasts in other tumors such as lung, pancreas or colorectal. Cattle ACE(Angiotensin I Converting Enzyme) ELISA Kit; Cattle ADM(Adrenomedullin) ELISA Kit; Cattle ADP(Adiponectin) ELISA Kit; Cattle aFP(Alpha-Fetoprotein) ELISA Kit; Cat Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Methods: Expression levels were determined using quantitative reverse transcription-polymerase chain reaction, and the percentage of DNA methylation was … Two hundred and one breast Core Needle Biopsy … is extremely low.
Application: NZ20040544518 on 2004-06-17. Item Properties: Gene >> Collagen Type IX Alpha 1. Objective: To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. Share. Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene..
It should be noted that while, in theory, two different sequences could
By using our services, you agree to our use of cookies. Collagen Type IX Alpha 1 (COL9a1) Polyclonal Antibody (Rat) Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type … This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Our analysis shows that several genes encode proteins expressed in the hyaloid membrane: namely, collagen type IX alpha 2 chain and collagen type IX alpha 3 chain COL9A3, which are also expressed in hyaline cartilage, and opticin .
This indicates the type of evidence that supports the existence of the protein. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. Wallis GA, Starman BJ, Zinn AB, Byers PH: Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism … Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a … UniParc. Mutations in this gene are associated with osteoarthritis in … Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. [1] [2]This gene encodes the major type IV alpha collagen chain of basement membranes. Traits Liquid; Concentration 500µg/mL with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi,
Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
References ^ a b c GRCh38: Ensembl release 89: … It also includes information pertinent to the sequence(s), including length and molecular weight. 1 Function; 2 Gene; 3 Clinical significance; 4 Further reading; 5 External links; Function. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.
This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Finden Sie perfekte Stock-Fotos zum Thema Collagen, Type I, Alpha 1 sowie redaktionelle Newsbilder von Getty Images. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Pages. The alpha 1 (IX) chain has two forms, as a result of the tissue-specific utilization of two alternative … Type IX molecules are localized on the surface of type II-containing fibrils and consist of two arms, a long arm that is crosslinked to type II collagen and a short arm that projects into the perifibrillar space. COL9A2; collagen type IX alpha 2 chain [KO:K08131] 1299 : COL9A3; collagen type IX alpha 3 chain [KO:K08131] 1300 : COL10A1; collagen type X alpha 1 chain [KO:K19479] 1303 : COL12A1; collagen type XII alpha 1 chain [KO:K08132] 1305 : COL13A1; collagen type XIII alpha 1 chain [KO:K16617] 7373 : COL14A1; collagen type XIV alpha 1 chain [KO:K08133] 1306 : COL15A1; …
Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
Type IX collagen, a heterotrimer of alpha-1 (COL9A1; 120210), alpha-2, and alpha-3 (COL9A3; 120270) chains specific for this type of collagen, is a cartilage-specific fibril-associated collagen (Perala et al., 1993). This is known as the 'taxonomic identifier' or 'taxid'.
This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding.An … Type IX collagen is made up of three proteins that are produced from three distinct genes: one α1(IX) chain, which is produced from the COL9A1 gene, one α2(IX) chain, which is produced from the COL9A2 gene, and one α3(IX) chain, which is produced from the COL9A3 gene. Format: Liquid. collagen, type IX, alpha 1: Background: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. collagen, type IX, alpha 1: Background: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. The triple helix of type IX collagen is composed of 3 genetically distinct polypeptide subunits--alpha-1 (IX), alpha-2 (IX), and alpha-3 (IX). The current subsections and their content are listed below:
The checksum is a form of redundancy check that is calculated
Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, … Using oligonucleotide primers specific for exons 4, 8, and the alternative exon (exon 1*), we demonstrated by the polymerase chain reaction that embryonic mouse and fetal human RNAs contain two types of alpha 1(IX) collagen transcripts. A different approach was taken by Bonde et al., who used a synthetic eight amino … Collagen, type IX, alpha 3. Protein knowledgebase. Collagen is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Cochlin. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. 1985 May;82(9):2870-4. Alpha Foods setzt auf kontrollierte Rohstoffqualität und wirbt transparent mit der Nähe zu ihren Zulieferern. Bei einer Menge von 450g gehört es zu den höherpreisigen Produkten, jedoch ist der Preis aufgrund der hohen Qualität berechtigt. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common … Jetzt Produkt ABIN6019869 bestellen. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Infectious Diseases; SARS-CoV-2 Antibodies; SARS-CoV-2 Spike Antibodies; SARS-CoV-2 Spike Proteins; … COL9A1 (Collagen Type IX Alpha 1 Chain) is a Protein Coding gene.
Mutations in this gene are associated with osteoarthritis in … [5] [6] [7] This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Polyclonal Antibody to Collagen Type IX Alpha 1 (COL9a1) COL9-A1; MED; Collagen Alpha-1(IX)chain. Collagen alpha-1 (XII) chain is a protein that in humans is encoded by the COL12A1 gene. OR (match all products having any of the selected features) AND (match only products having all selected features) All None 89: … Collagen IX alpha 1 Antibody detects endogenous levels of total Collagen IX alpha 1. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. Protein that in humans is encoded by the COL9A3 gene. Mutations in this gene may be associated with multiple epiphyseal dysplasia.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.
UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling … Specification accepted - New Zealand. from the sequence. Both mouse …
The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage. [2], 2uur: N-TERMINAL NC4 DOMAIN OF COLLAGEN IX. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),
This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. COL9A1, collagen type IX alpha 1 chain Vertebrate Orthologs 10 Human Ortholog COL9A1, collagen type IX alpha 1 chain Orthology source: HomoloGene, HGNC Synonyms DJ149L1.1.2, EDM6, MED, STL4 Links HGNC:2217. Type IX collagen is also a proteoglycan. Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Extracellular matrix protein highly abundant in the cochlea and vestibule of the inner ear, constituting the major non-collagen component of the ECM of the inner ear. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding. Find link is a tool written by Edward Betts.. searching for Collagen, type IX, alpha 1 1 found (4 total) alternate case: collagen, type IX, alpha 1 Multiple epiphyseal dysplasia (2,382 words) no match in snippet view article find links to article Epiphyseal Dysplasia (MED) – Pediatrics – Orthobullets".
IPR001791 Laminin G domain. Interpolated concentrations of native Pro-Collagen I alpha 1 in human IMR-90 extract based on a 2 µg/mL extract load. Wikipedia. Mutations in this gene are associated with osteoarthritis in … This degradation byproduct has been deemed CXM and has potential to be a useful biomarker to assess real time growth velocity in children and fracture healing in adults. In hyaline cartilage, the alpha 1(IX) collagen … Product No. Diseases associated with COL9A1 include Epiphyseal Dysplasia, Multiple, 6 and Stickler Syndrome, Type Iv. Recombinant Collagen, Type IX, alpha 1 (COL9A1) Protein. By cross-hybridization using a chicken type V collagen probe, Yoshioka et al.
Collagen type IX alpha 1 chain NC4 domains for treating arthritis (PAT - NZ544518) ' ' GHOSH PETER PROTEOBIOACTIVES PTY LTD. Patent: Comp. Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). AffiliateLink . Ig Type IgG; Purification Antigen-specific affinity chromatography followed by Protein A affinity chromatography; Label None; Immunogen RPC145Ra01-Recombinant Collagen Type IX Alpha 1 (COL9a1) Buffer Formulation PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. Help. Contents. Background: Collagen I alpha 1. COL1A1 / Collagen I Alpha 1 is the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. The COL1A1 gene produces a component of type I collagen, called the collagen, type I, alpha 1. Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon.
COL9A1, collagen type IX alpha 1 chain Orthology source: HomoloGene, HGNC Synonyms DJ149L1.1.2, EDM6, MED, STL4 ... PR:000005722 collagen alpha-1(IX) chain (term hierarchy) InterPro Domains. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Das beste Collagen Pulver in der 1 kg Packung. "collagen, type I, alpha 1" LocusID (NCBI) 1277: Atlas_Id: 186: Location: 17q21.33 [Link to chromosome band 17q21] Location_base_pair: Starts at 50184101 and ends at 50201631 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping COL1A1.png] Local_order: Telomeric to MEOX1 (mesenchyme homeo box 1), centromeric to MVWF (Modifier of von Willebrand … … Collagen I alpha 1: Products. The crosslinks result in the formation of mature type XI collagen fibers, with the help of collagen types II and IX. Open Advanced Filter 13 Applications, 21 Species currently selected. Collagen alpha-1(X) undergoes degradation in the active growth plate releasing an intact NC1 region with a small amount of collagenous region attached. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. COL9A1 (Collagen Type IX Alpha 1 Chain) is a Protein Coding gene. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. It is useful for tracking sequence updates.
[1][2], This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Collagen alpha-1 (X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. These are stable identifiers and should be used to cite UniProtKB entries. Protein sets from fully sequenced genomes. Diseases associated with COL9A1 include Epiphyseal Dysplasia, Multiple, 6 and Stickler Syndrome, Type Iv.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include extracellular matrix structural … have the same checksum value, the likelihood that this would happen
Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are … These are the products of genes whose exon structure is different from that of fibrillar collagens. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Type XI collagen is broadly distributed in articular cartilage, testis, trachea, tendons, trabecular bone, skeletal muscle, placenta, lung, and the neoepithelium of the brain , . Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.
This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Genes similar to or like Collagen, type IX, alpha 3. Spezies: Ratte. RRID: AB_2842100 Please cite this product as: Affinity Biosciences Cat# DF8904, RRID:AB_2842100. "Entrez Gene: COL9A1 collagen, type IX, alpha 1", GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant, GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome, "The alpha 1 (IX) collagen gene gives rise to two different transcripts in both mouse embryonic and human fetal RNA", "Characterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituents", "Structure of the glycosaminoglycan domain in the type IX collagen-proteoglycan", "Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites", "A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity", "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", https://www.wikidoc.org/index.php?title=Collagen,_type_IX,_alpha_1&oldid=1420921, Creative Commons Attribution/Share-Alike License, This page was last edited 15:25, 30 August 2017 by wikidoc anonymous user. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.
This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. The novel collagen chain was arbitrarily termed alpha-1(Y) and assigned the D segment number D6S228E. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family.
However UniProtKB may contain entries with identical sequences in case
Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. : PAC145Ra01 >> Metabolic pathway; Ophthalmology & Otorhinolaryngology; Developmental science; Nutrition metabolism; Rheumatology; Autoimmunity; Product No. We also observed significantly altered expression levels of genes including interleukine 13 receptor subunit alpha 2 (IL13RA2), transforming growth factor beta 1 (TGFβ1), collagen type III alpha 1 chain (COL3A1), and collagen type IX alpha 3 chain (COL9A3), implying immunosuppression, fibrosis development, and collagen deposition. Summary: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Researchers believe that the flexible nature of type IX collagen … Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
This subsection of the 'Entry information' section provides one or more accession number(s). Publication: 2009-12-24. collagen, type IX, alpha 1: LocusID (NCBI) 1297: Atlas_Id: 62003: Location: 6q13 [Link to chromosome band 6q13] Location_base_pair: Starts at 70216040 and ends at 70283208 bp from pter ( according to hg38-Dec_2013) Fusion genes (updated 2017) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see …
This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. You are using a version of browser that may not display all the features of this website. Proc Natl Acad Sci U S A. Collagen Type I Alpha 1 Chain is also known as Alpha-1 type I collagen, CO1A1, COL1A1, Cola1, Collagen alpha-1(I) chain, collagen I, Collagen I,II,III,IV,V, Collagen Types I, III, PICP . The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are … Molecular Reagents less. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Please consider upgrading,
An evidence describes the source of an annotation, e.g. Nach oben. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. IPR013320 Concanavalin A-like lectin/glucanase domain superfamily. Storage Condition and Buffer: an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
(1992) isolated from a human rhabdomyosarcoma cell line a 1.8-kb cDNA encoding a portion of a novel collagen chain with a structure similar to that of the FACIT class of macromolecules. UniProtKB. Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene. using the generator polynomial: x64 + x4 + x3 + x + 1. One type of transcript does not contain the sequence encoded by exon 1*; the second type of transcript contains this exon.
Contact Resources Top Antigen Products Popular Categories. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. At this point, Collagen, type XI, alpha 1 (COL11A1), might be helpful since it has been described to be associated to cancer associated fibroblasts in other tumors such as lung, pancreas or colorectal. Cattle ACE(Angiotensin I Converting Enzyme) ELISA Kit; Cattle ADM(Adrenomedullin) ELISA Kit; Cattle ADP(Adiponectin) ELISA Kit; Cattle aFP(Alpha-Fetoprotein) ELISA Kit; Cat Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Methods: Expression levels were determined using quantitative reverse transcription-polymerase chain reaction, and the percentage of DNA methylation was … Two hundred and one breast Core Needle Biopsy … is extremely low.
Application: NZ20040544518 on 2004-06-17. Item Properties: Gene >> Collagen Type IX Alpha 1. Objective: To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. Share. Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene..
It should be noted that while, in theory, two different sequences could
By using our services, you agree to our use of cookies. Collagen Type IX Alpha 1 (COL9a1) Polyclonal Antibody (Rat) Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type … This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Our analysis shows that several genes encode proteins expressed in the hyaloid membrane: namely, collagen type IX alpha 2 chain and collagen type IX alpha 3 chain COL9A3, which are also expressed in hyaline cartilage, and opticin .
This indicates the type of evidence that supports the existence of the protein. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. Wallis GA, Starman BJ, Zinn AB, Byers PH: Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism … Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a … UniParc. Mutations in this gene are associated with osteoarthritis in … Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. [1] [2]This gene encodes the major type IV alpha collagen chain of basement membranes. Traits Liquid; Concentration 500µg/mL with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi,
Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
References ^ a b c GRCh38: Ensembl release 89: … It also includes information pertinent to the sequence(s), including length and molecular weight. 1 Function; 2 Gene; 3 Clinical significance; 4 Further reading; 5 External links; Function. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.
This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Finden Sie perfekte Stock-Fotos zum Thema Collagen, Type I, Alpha 1 sowie redaktionelle Newsbilder von Getty Images. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Pages. The alpha 1 (IX) chain has two forms, as a result of the tissue-specific utilization of two alternative … Type IX molecules are localized on the surface of type II-containing fibrils and consist of two arms, a long arm that is crosslinked to type II collagen and a short arm that projects into the perifibrillar space. COL9A2; collagen type IX alpha 2 chain [KO:K08131] 1299 : COL9A3; collagen type IX alpha 3 chain [KO:K08131] 1300 : COL10A1; collagen type X alpha 1 chain [KO:K19479] 1303 : COL12A1; collagen type XII alpha 1 chain [KO:K08132] 1305 : COL13A1; collagen type XIII alpha 1 chain [KO:K16617] 7373 : COL14A1; collagen type XIV alpha 1 chain [KO:K08133] 1306 : COL15A1; …
Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
Type IX collagen, a heterotrimer of alpha-1 (COL9A1; 120210), alpha-2, and alpha-3 (COL9A3; 120270) chains specific for this type of collagen, is a cartilage-specific fibril-associated collagen (Perala et al., 1993). This is known as the 'taxonomic identifier' or 'taxid'.
This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding.An … Type IX collagen is made up of three proteins that are produced from three distinct genes: one α1(IX) chain, which is produced from the COL9A1 gene, one α2(IX) chain, which is produced from the COL9A2 gene, and one α3(IX) chain, which is produced from the COL9A3 gene. Format: Liquid. collagen, type IX, alpha 1: Background: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. collagen, type IX, alpha 1: Background: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. The triple helix of type IX collagen is composed of 3 genetically distinct polypeptide subunits--alpha-1 (IX), alpha-2 (IX), and alpha-3 (IX). The current subsections and their content are listed below:
The checksum is a form of redundancy check that is calculated
Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, … Using oligonucleotide primers specific for exons 4, 8, and the alternative exon (exon 1*), we demonstrated by the polymerase chain reaction that embryonic mouse and fetal human RNAs contain two types of alpha 1(IX) collagen transcripts. A different approach was taken by Bonde et al., who used a synthetic eight amino … Collagen, type IX, alpha 3. Protein knowledgebase. Collagen is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Cochlin. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. 1985 May;82(9):2870-4. Alpha Foods setzt auf kontrollierte Rohstoffqualität und wirbt transparent mit der Nähe zu ihren Zulieferern. Bei einer Menge von 450g gehört es zu den höherpreisigen Produkten, jedoch ist der Preis aufgrund der hohen Qualität berechtigt. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common … Jetzt Produkt ABIN6019869 bestellen. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Infectious Diseases; SARS-CoV-2 Antibodies; SARS-CoV-2 Spike Antibodies; SARS-CoV-2 Spike Proteins; … COL9A1 (Collagen Type IX Alpha 1 Chain) is a Protein Coding gene.
Mutations in this gene are associated with osteoarthritis in … [5] [6] [7] This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Polyclonal Antibody to Collagen Type IX Alpha 1 (COL9a1) COL9-A1; MED; Collagen Alpha-1(IX)chain. Collagen alpha-1 (XII) chain is a protein that in humans is encoded by the COL12A1 gene. OR (match all products having any of the selected features) AND (match only products having all selected features) All None 89: … Collagen IX alpha 1 Antibody detects endogenous levels of total Collagen IX alpha 1. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. Protein that in humans is encoded by the COL9A3 gene. Mutations in this gene may be associated with multiple epiphyseal dysplasia.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.
UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling … Specification accepted - New Zealand. from the sequence. Both mouse …
The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage. [2], 2uur: N-TERMINAL NC4 DOMAIN OF COLLAGEN IX. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),
This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. COL9A1, collagen type IX alpha 1 chain Vertebrate Orthologs 10 Human Ortholog COL9A1, collagen type IX alpha 1 chain Orthology source: HomoloGene, HGNC Synonyms DJ149L1.1.2, EDM6, MED, STL4 Links HGNC:2217. Type IX collagen is also a proteoglycan. Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Extracellular matrix protein highly abundant in the cochlea and vestibule of the inner ear, constituting the major non-collagen component of the ECM of the inner ear. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding. Find link is a tool written by Edward Betts.. searching for Collagen, type IX, alpha 1 1 found (4 total) alternate case: collagen, type IX, alpha 1 Multiple epiphyseal dysplasia (2,382 words) no match in snippet view article find links to article Epiphyseal Dysplasia (MED) – Pediatrics – Orthobullets".
IPR001791 Laminin G domain. Interpolated concentrations of native Pro-Collagen I alpha 1 in human IMR-90 extract based on a 2 µg/mL extract load. Wikipedia. Mutations in this gene are associated with osteoarthritis in … This degradation byproduct has been deemed CXM and has potential to be a useful biomarker to assess real time growth velocity in children and fracture healing in adults. In hyaline cartilage, the alpha 1(IX) collagen … Product No. Diseases associated with COL9A1 include Epiphyseal Dysplasia, Multiple, 6 and Stickler Syndrome, Type Iv. Recombinant Collagen, Type IX, alpha 1 (COL9A1) Protein. By cross-hybridization using a chicken type V collagen probe, Yoshioka et al.
Collagen type IX alpha 1 chain NC4 domains for treating arthritis (PAT - NZ544518) ' ' GHOSH PETER PROTEOBIOACTIVES PTY LTD. Patent: Comp. Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). AffiliateLink . Ig Type IgG; Purification Antigen-specific affinity chromatography followed by Protein A affinity chromatography; Label None; Immunogen RPC145Ra01-Recombinant Collagen Type IX Alpha 1 (COL9a1) Buffer Formulation PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. Help. Contents. Background: Collagen I alpha 1. COL1A1 / Collagen I Alpha 1 is the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. The COL1A1 gene produces a component of type I collagen, called the collagen, type I, alpha 1. Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon.
COL9A1, collagen type IX alpha 1 chain Orthology source: HomoloGene, HGNC Synonyms DJ149L1.1.2, EDM6, MED, STL4 ... PR:000005722 collagen alpha-1(IX) chain (term hierarchy) InterPro Domains. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Das beste Collagen Pulver in der 1 kg Packung. "collagen, type I, alpha 1" LocusID (NCBI) 1277: Atlas_Id: 186: Location: 17q21.33 [Link to chromosome band 17q21] Location_base_pair: Starts at 50184101 and ends at 50201631 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping COL1A1.png] Local_order: Telomeric to MEOX1 (mesenchyme homeo box 1), centromeric to MVWF (Modifier of von Willebrand … … Collagen I alpha 1: Products. The crosslinks result in the formation of mature type XI collagen fibers, with the help of collagen types II and IX. Open Advanced Filter 13 Applications, 21 Species currently selected. Collagen alpha-1(X) undergoes degradation in the active growth plate releasing an intact NC1 region with a small amount of collagenous region attached. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. COL9A1 (Collagen Type IX Alpha 1 Chain) is a Protein Coding gene. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. It is useful for tracking sequence updates.
[1][2], This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Collagen alpha-1 (X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. These are stable identifiers and should be used to cite UniProtKB entries. Protein sets from fully sequenced genomes. Diseases associated with COL9A1 include Epiphyseal Dysplasia, Multiple, 6 and Stickler Syndrome, Type Iv.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include extracellular matrix structural … have the same checksum value, the likelihood that this would happen
Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are … These are the products of genes whose exon structure is different from that of fibrillar collagens. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Type XI collagen is broadly distributed in articular cartilage, testis, trachea, tendons, trabecular bone, skeletal muscle, placenta, lung, and the neoepithelium of the brain , . Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.
This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Genes similar to or like Collagen, type IX, alpha 3. Spezies: Ratte. RRID: AB_2842100 Please cite this product as: Affinity Biosciences Cat# DF8904, RRID:AB_2842100. "Entrez Gene: COL9A1 collagen, type IX, alpha 1", GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant, GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome, "The alpha 1 (IX) collagen gene gives rise to two different transcripts in both mouse embryonic and human fetal RNA", "Characterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituents", "Structure of the glycosaminoglycan domain in the type IX collagen-proteoglycan", "Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites", "A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity", "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", https://www.wikidoc.org/index.php?title=Collagen,_type_IX,_alpha_1&oldid=1420921, Creative Commons Attribution/Share-Alike License, This page was last edited 15:25, 30 August 2017 by wikidoc anonymous user. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.
This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. The novel collagen chain was arbitrarily termed alpha-1(Y) and assigned the D segment number D6S228E. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family.
However UniProtKB may contain entries with identical sequences in case
Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. : PAC145Ra01 >> Metabolic pathway; Ophthalmology & Otorhinolaryngology; Developmental science; Nutrition metabolism; Rheumatology; Autoimmunity; Product No. We also observed significantly altered expression levels of genes including interleukine 13 receptor subunit alpha 2 (IL13RA2), transforming growth factor beta 1 (TGFβ1), collagen type III alpha 1 chain (COL3A1), and collagen type IX alpha 3 chain (COL9A3), implying immunosuppression, fibrosis development, and collagen deposition. Summary: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Researchers believe that the flexible nature of type IX collagen … Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
This subsection of the 'Entry information' section provides one or more accession number(s). Publication: 2009-12-24. collagen, type IX, alpha 1: LocusID (NCBI) 1297: Atlas_Id: 62003: Location: 6q13 [Link to chromosome band 6q13] Location_base_pair: Starts at 70216040 and ends at 70283208 bp from pter ( according to hg38-Dec_2013) Fusion genes (updated 2017) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see …
x; UniProtKB. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. We'd like to inform you that we have updated our Privacy Notice to comply Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis.
This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. You are using a version of browser that may not display all the features of this website. Proc Natl Acad Sci U S A. Collagen Type I Alpha 1 Chain is also known as Alpha-1 type I collagen, CO1A1, COL1A1, Cola1, Collagen alpha-1(I) chain, collagen I, Collagen I,II,III,IV,V, Collagen Types I, III, PICP . The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are … Molecular Reagents less. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Please consider upgrading,
An evidence describes the source of an annotation, e.g. Nach oben. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. IPR013320 Concanavalin A-like lectin/glucanase domain superfamily. Storage Condition and Buffer: an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
(1992) isolated from a human rhabdomyosarcoma cell line a 1.8-kb cDNA encoding a portion of a novel collagen chain with a structure similar to that of the FACIT class of macromolecules. UniProtKB. Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene. using the generator polynomial: x64 + x4 + x3 + x + 1. One type of transcript does not contain the sequence encoded by exon 1*; the second type of transcript contains this exon.
Contact Resources Top Antigen Products Popular Categories. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. At this point, Collagen, type XI, alpha 1 (COL11A1), might be helpful since it has been described to be associated to cancer associated fibroblasts in other tumors such as lung, pancreas or colorectal. Cattle ACE(Angiotensin I Converting Enzyme) ELISA Kit; Cattle ADM(Adrenomedullin) ELISA Kit; Cattle ADP(Adiponectin) ELISA Kit; Cattle aFP(Alpha-Fetoprotein) ELISA Kit; Cat Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Methods: Expression levels were determined using quantitative reverse transcription-polymerase chain reaction, and the percentage of DNA methylation was … Two hundred and one breast Core Needle Biopsy … is extremely low.
Application: NZ20040544518 on 2004-06-17. Item Properties: Gene >> Collagen Type IX Alpha 1. Objective: To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. Share. Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene..
It should be noted that while, in theory, two different sequences could
By using our services, you agree to our use of cookies. Collagen Type IX Alpha 1 (COL9a1) Polyclonal Antibody (Rat) Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type … This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Our analysis shows that several genes encode proteins expressed in the hyaloid membrane: namely, collagen type IX alpha 2 chain and collagen type IX alpha 3 chain COL9A3, which are also expressed in hyaline cartilage, and opticin .
This indicates the type of evidence that supports the existence of the protein. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. Wallis GA, Starman BJ, Zinn AB, Byers PH: Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism … Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a … UniParc. Mutations in this gene are associated with osteoarthritis in … Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. [1] [2]This gene encodes the major type IV alpha collagen chain of basement membranes. Traits Liquid; Concentration 500µg/mL with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi,
Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
References ^ a b c GRCh38: Ensembl release 89: … It also includes information pertinent to the sequence(s), including length and molecular weight. 1 Function; 2 Gene; 3 Clinical significance; 4 Further reading; 5 External links; Function. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.
This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Finden Sie perfekte Stock-Fotos zum Thema Collagen, Type I, Alpha 1 sowie redaktionelle Newsbilder von Getty Images. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Pages. The alpha 1 (IX) chain has two forms, as a result of the tissue-specific utilization of two alternative … Type IX molecules are localized on the surface of type II-containing fibrils and consist of two arms, a long arm that is crosslinked to type II collagen and a short arm that projects into the perifibrillar space. COL9A2; collagen type IX alpha 2 chain [KO:K08131] 1299 : COL9A3; collagen type IX alpha 3 chain [KO:K08131] 1300 : COL10A1; collagen type X alpha 1 chain [KO:K19479] 1303 : COL12A1; collagen type XII alpha 1 chain [KO:K08132] 1305 : COL13A1; collagen type XIII alpha 1 chain [KO:K16617] 7373 : COL14A1; collagen type XIV alpha 1 chain [KO:K08133] 1306 : COL15A1; …
Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
Type IX collagen, a heterotrimer of alpha-1 (COL9A1; 120210), alpha-2, and alpha-3 (COL9A3; 120270) chains specific for this type of collagen, is a cartilage-specific fibril-associated collagen (Perala et al., 1993). This is known as the 'taxonomic identifier' or 'taxid'.
This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding.An … Type IX collagen is made up of three proteins that are produced from three distinct genes: one α1(IX) chain, which is produced from the COL9A1 gene, one α2(IX) chain, which is produced from the COL9A2 gene, and one α3(IX) chain, which is produced from the COL9A3 gene. Format: Liquid. collagen, type IX, alpha 1: Background: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. collagen, type IX, alpha 1: Background: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. The triple helix of type IX collagen is composed of 3 genetically distinct polypeptide subunits--alpha-1 (IX), alpha-2 (IX), and alpha-3 (IX). The current subsections and their content are listed below:
The checksum is a form of redundancy check that is calculated
Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, … Using oligonucleotide primers specific for exons 4, 8, and the alternative exon (exon 1*), we demonstrated by the polymerase chain reaction that embryonic mouse and fetal human RNAs contain two types of alpha 1(IX) collagen transcripts. A different approach was taken by Bonde et al., who used a synthetic eight amino … Collagen, type IX, alpha 3. Protein knowledgebase. Collagen is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Cochlin. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. 1985 May;82(9):2870-4. Alpha Foods setzt auf kontrollierte Rohstoffqualität und wirbt transparent mit der Nähe zu ihren Zulieferern. Bei einer Menge von 450g gehört es zu den höherpreisigen Produkten, jedoch ist der Preis aufgrund der hohen Qualität berechtigt. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common … Jetzt Produkt ABIN6019869 bestellen. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Infectious Diseases; SARS-CoV-2 Antibodies; SARS-CoV-2 Spike Antibodies; SARS-CoV-2 Spike Proteins; … COL9A1 (Collagen Type IX Alpha 1 Chain) is a Protein Coding gene.
Mutations in this gene are associated with osteoarthritis in … [5] [6] [7] This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Polyclonal Antibody to Collagen Type IX Alpha 1 (COL9a1) COL9-A1; MED; Collagen Alpha-1(IX)chain. Collagen alpha-1 (XII) chain is a protein that in humans is encoded by the COL12A1 gene. OR (match all products having any of the selected features) AND (match only products having all selected features) All None 89: … Collagen IX alpha 1 Antibody detects endogenous levels of total Collagen IX alpha 1. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. Protein that in humans is encoded by the COL9A3 gene. Mutations in this gene may be associated with multiple epiphyseal dysplasia.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.
UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling … Specification accepted - New Zealand. from the sequence. Both mouse …
The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage. [2], 2uur: N-TERMINAL NC4 DOMAIN OF COLLAGEN IX. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),
This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. COL9A1, collagen type IX alpha 1 chain Vertebrate Orthologs 10 Human Ortholog COL9A1, collagen type IX alpha 1 chain Orthology source: HomoloGene, HGNC Synonyms DJ149L1.1.2, EDM6, MED, STL4 Links HGNC:2217. Type IX collagen is also a proteoglycan. Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Extracellular matrix protein highly abundant in the cochlea and vestibule of the inner ear, constituting the major non-collagen component of the ECM of the inner ear. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include identical protein binding and platelet-derived growth factor binding. Find link is a tool written by Edward Betts.. searching for Collagen, type IX, alpha 1 1 found (4 total) alternate case: collagen, type IX, alpha 1 Multiple epiphyseal dysplasia (2,382 words) no match in snippet view article find links to article Epiphyseal Dysplasia (MED) – Pediatrics – Orthobullets".
IPR001791 Laminin G domain. Interpolated concentrations of native Pro-Collagen I alpha 1 in human IMR-90 extract based on a 2 µg/mL extract load. Wikipedia. Mutations in this gene are associated with osteoarthritis in … This degradation byproduct has been deemed CXM and has potential to be a useful biomarker to assess real time growth velocity in children and fracture healing in adults. In hyaline cartilage, the alpha 1(IX) collagen … Product No. Diseases associated with COL9A1 include Epiphyseal Dysplasia, Multiple, 6 and Stickler Syndrome, Type Iv. Recombinant Collagen, Type IX, alpha 1 (COL9A1) Protein. By cross-hybridization using a chicken type V collagen probe, Yoshioka et al.
Collagen type IX alpha 1 chain NC4 domains for treating arthritis (PAT - NZ544518) ' ' GHOSH PETER PROTEOBIOACTIVES PTY LTD. Patent: Comp. Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). AffiliateLink . Ig Type IgG; Purification Antigen-specific affinity chromatography followed by Protein A affinity chromatography; Label None; Immunogen RPC145Ra01-Recombinant Collagen Type IX Alpha 1 (COL9a1) Buffer Formulation PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. Help. Contents. Background: Collagen I alpha 1. COL1A1 / Collagen I Alpha 1 is the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. The COL1A1 gene produces a component of type I collagen, called the collagen, type I, alpha 1. Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon.
COL9A1, collagen type IX alpha 1 chain Orthology source: HomoloGene, HGNC Synonyms DJ149L1.1.2, EDM6, MED, STL4 ... PR:000005722 collagen alpha-1(IX) chain (term hierarchy) InterPro Domains. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Das beste Collagen Pulver in der 1 kg Packung. "collagen, type I, alpha 1" LocusID (NCBI) 1277: Atlas_Id: 186: Location: 17q21.33 [Link to chromosome band 17q21] Location_base_pair: Starts at 50184101 and ends at 50201631 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping COL1A1.png] Local_order: Telomeric to MEOX1 (mesenchyme homeo box 1), centromeric to MVWF (Modifier of von Willebrand … … Collagen I alpha 1: Products. The crosslinks result in the formation of mature type XI collagen fibers, with the help of collagen types II and IX. Open Advanced Filter 13 Applications, 21 Species currently selected. Collagen alpha-1(X) undergoes degradation in the active growth plate releasing an intact NC1 region with a small amount of collagenous region attached. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. COL9A1 (Collagen Type IX Alpha 1 Chain) is a Protein Coding gene. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. It is useful for tracking sequence updates.
[1][2], This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. Collagen alpha-1(IV) chain is a protein that in humans is encoded by the COL4A1 gene. Collagen alpha-1 (X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. These are stable identifiers and should be used to cite UniProtKB entries. Protein sets from fully sequenced genomes. Diseases associated with COL9A1 include Epiphyseal Dysplasia, Multiple, 6 and Stickler Syndrome, Type Iv.Among its related pathways are Collagen chain trimerization and Integrin Pathway.Gene Ontology (GO) annotations related to this gene include extracellular matrix structural … have the same checksum value, the likelihood that this would happen
Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are … These are the products of genes whose exon structure is different from that of fibrillar collagens. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Type XI collagen is broadly distributed in articular cartilage, testis, trachea, tendons, trabecular bone, skeletal muscle, placenta, lung, and the neoepithelium of the brain , . Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.
This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Genes similar to or like Collagen, type IX, alpha 3. Spezies: Ratte. RRID: AB_2842100 Please cite this product as: Affinity Biosciences Cat# DF8904, RRID:AB_2842100. "Entrez Gene: COL9A1 collagen, type IX, alpha 1", GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant, GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome, "The alpha 1 (IX) collagen gene gives rise to two different transcripts in both mouse embryonic and human fetal RNA", "Characterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituents", "Structure of the glycosaminoglycan domain in the type IX collagen-proteoglycan", "Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites", "A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity", "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", https://www.wikidoc.org/index.php?title=Collagen,_type_IX,_alpha_1&oldid=1420921, Creative Commons Attribution/Share-Alike License, This page was last edited 15:25, 30 August 2017 by wikidoc anonymous user. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.
This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. The novel collagen chain was arbitrarily termed alpha-1(Y) and assigned the D segment number D6S228E. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family.
However UniProtKB may contain entries with identical sequences in case
Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. : PAC145Ra01 >> Metabolic pathway; Ophthalmology & Otorhinolaryngology; Developmental science; Nutrition metabolism; Rheumatology; Autoimmunity; Product No. We also observed significantly altered expression levels of genes including interleukine 13 receptor subunit alpha 2 (IL13RA2), transforming growth factor beta 1 (TGFβ1), collagen type III alpha 1 chain (COL3A1), and collagen type IX alpha 3 chain (COL9A3), implying immunosuppression, fibrosis development, and collagen deposition. Summary: This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Researchers believe that the flexible nature of type IX collagen … Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
This subsection of the 'Entry information' section provides one or more accession number(s). Publication: 2009-12-24. collagen, type IX, alpha 1: LocusID (NCBI) 1297: Atlas_Id: 62003: Location: 6q13 [Link to chromosome band 6q13] Location_base_pair: Starts at 70216040 and ends at 70283208 bp from pter ( according to hg38-Dec_2013) Fusion genes (updated 2017) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see …